Gatifloxacin resistance and mutations in gyra after unsuccessful Helicobacter pylori eradication in Japan.
نویسندگان
چکیده
A high resistance rate (47.9%) to gatifloxacin (GAT; 8-methoxy fluoroquinolone) in Helicobacter pylori (H. pylori) strains from 48 Japanese patients is observed after unsuccessful H. pylori eradication. A significant association between MICs for GAT equal to or above 1 microg/ml and mutations of the gyrA gene of H. pylori was demonstrated.
منابع مشابه
Sitafloxacin and garenoxacin may overcome the antibiotic resistance of Helicobacter pylori with gyrA mutation.
Resistance of Helicobacter pylori to the standard therapeutic antimicrobials (clarithromycin, metronidazole, amoxicillin [AMX], and tetracycline) (9) has been demonstrated; therefore, there is an urgent need to introduce other treatment options. Fluoroquinolones, such as levofloxacin (LVX) and gatifloxacin (GAT), have been evaluated as an alternative to standard antibiotics against H. pylori. A...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 50 4 شماره
صفحات -
تاریخ انتشار 2006